Predictors of survival and technical success of bronchoscopic interventions in malignant airway obstruction.

Freitas C, Serino M, Cardoso C, Saleiro S, Vaz AP, Novais-Bastos H, Morais A, Magalhães A, Fernandes G. J

Thorac Dis. 2021 Dec;13(12):6760-6768. doi: 10.21037/jtd-21-1393. PMID: 35070360; PMCID: PMC8743414.

What is the key question?

  • Determination of factors to assist in the selection of patients with potential better outcomes from bronchoscopic interventions for their malignant airways obstruction.

What is the bottom line?

  • This was a single-centre prospective study that included 100 patients with proximal malignant airway obstructions and underwent intervention.
  • Majority of patients had squamous cell lung cancer, and a Stage IV diagnosis. Most also had cancer diagnosed at their initial central airway obstruction-related presentation.
  • Median cohort survival was 8 months.
  • Those with extrinsic or mixed extrinsic-intrinsic obstruction had shorter survival.
  • Technical success of the bronchoscopic interventions were found to be related to airway patency distal to the obstruction and shorter obstruction length.

Why read on?

  • The authors further detail other factors that were associated with better survival, to possibly assist with decision-making in intervening for malignant central airway obstruction.